HypC, the anthrone oxidase involved in aflatoxin biosynthesis.
نویسندگان
چکیده
On the basis of gene disruption and enzyme activity, hypC, an open reading frame in the region between the pksA (aflC) and nor-1 (aflD) genes in the aflatoxin biosynthesis gene cluster, encodes a 17-kDa oxidase that converts norsolorinic acid anthrone to norsolorinic acid.
منابع مشابه
Predicted Roles of the Uncharacterized Clustered Genes in Aflatoxin Biosynthesis
Biosynthesis of the toxic and carcinogenic aflatoxins (AFs) requires the activity of more than 27 enzymes. The roles in biosynthesis of newly described enzymes are discussed in this review. We suggest that HypC catalyzes the oxidation of norsolorinic acid anthrone; AvfA (AflI), the ring-closure step in formation of hydroxyversicolorone; HypB, the second oxidation step in conversion of O-methyls...
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عنوان ژورنال:
- Applied and environmental microbiology
دوره 76 10 شماره
صفحات -
تاریخ انتشار 2010